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KMID : 1007020080060010014
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Korean Soceity of Osteroporosis
2008 Volume.6 No. 1 p.14 ~ p.22
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Serum Minerals and Bone Mineral Density In Pre- and Postmenopausal Women
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Kang Ree-Na
Song Chan-Hee
Ock Sun-Myeong
Choi Whan-Seok
Joo Sang-Yeon
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Abstract
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Objectives: Some minerals in serum have been known to be associated with bone mineral density (BMD) in postmenopausal women or people with certain chronic diseases, but the results of studies have not been consistent. The objective of the present study was to evaluate the independent association between serum minerals and BMD in pre- and postmenopausal women.
Methods: Sixty eight premenopausal, and fifty two postmenopausal women were recruited from out- patient clinics and a health promotion center in a university hospital located in Seoul for this cross-sectional study. All participants completed serum mineral analysis and BMD measurements at the spine and hip. For data analyses, multiple linear regression models were used.
Results: Higher BMD at the 3rd, 4th and total lumbar spine (L-spine) was significantly associated with lower serum magnesium in premenopausal women, but not in postmenopausal women. The ratio of serum calcium to magnesium was significantly and positively associated with BMD at all lumbar sites in premenopausal women, but not in postmenopausal women. Serum calcium tended to have a negative association with BMD at the 3rd, 4th and total L-spine in post menopausal women, but it was not significant (P=0.1).
Conclusion: Magnesium and the ratio of calcium to magnesium in the serum may serve as predictors for BMD in premenopausal women, but not in postmenopausal women.
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KEYWORD
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Serum mineral, Bone mineral density, Premenopause, Postmenopause
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